Although ABCA1 expression is also downregulated by c-Myc in breast cancer, no remarkable difference in c-Myc expression was observed between EpH4 and EpH4-Snail cells, indicating that c-Myc is not likely involved in ABCA1 expression in EpH4-Snail cells (Figure 2—figure supplement 1B). The gene discussed is MYC; the disease is breast carcinoma.