APP and Alzheimer disease: The result showed that Aβ plaque deposition in the hippocampal and cortical regions of APP/PS1 mice with SV2A overexpression was significantly reduced when compared to the control group mice, and the quantitative analysis of Aβ plaques showed that the number, the size, and the area of Aβ plaques were significantly reduced (Figure 1a,b), suggesting that SV2A reduced the amyloid plaque deposition in the brain regions of AD mice.