In addition, macrophage activation syndrome (MAS) [31], phagocytic lymphohistiocytosis (HLH) [32], CAR-T cell immunotherapy [33, 34], graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation [35], and acquired dysfunction of the NLRP3 gene leading to cryopyrin-associated periodic syndrome can also cause cytokine storms [36]. The gene discussed is NLRP3; the disease is graft versus host disease.