After Piezo1 is activated, the cytoplasm’s calcium influx increases to protect articular chondrocytes from mechanically induced cell death.123,124 The selective Piezo1 agonist Yoda1 has been found to increase the Ca2+ level in human chondrocytes with osteoarthritis and upregulate the expression of MMPs, tissue inhibitor of metalloproteinase 2, BMP2, type I collagen α1, and interleukin.125 Blocking the Piezo1/CaN/NFAT1 signaling axis can protect chondrocytes from apoptosis and anabolic/catabolic imbalance under mechanical strain. Here, PIEZO1 is linked to osteoarthritis.