Research has shown that ClC-7 plays a crucial role in craniofacial bone and tooth development and mineralization in zebrafish, influencing craniofacial bone and tooth changes in patients with osteosclerosis and dense bone dysplasia through the ClC-7/CTSK/TGF-β/BMP/SMAD signaling pathway.117. Here, CLCN7 is linked to osteosclerosis.