The present review summarizes (i) the mechanisms underlying hypoxia‐induced glycolysis that enhances the aggressiveness of and treatment failure in PCa and (ii) recent developments in the field of theranostic nanoparticles (TNPs) with dual actions of inhibiting HIF‐1a and downstream metabolic targets, while facilitating the imaging and treatment of the tumor. This evidence concerns the gene HIF1A and posterior cortical atrophy.