GNMT and Hepatic fibrosis: Broader changes in one-carbon related metabolism and the consequent impact on transcriptional events have not been fully explored.<h4>Objective</h4>The objective of this study was to identify common metabolic and transcriptional profiles in methionine and choline deficient (MCD) and glycine N-methyltransferase knockout (GNMTKO) mice to help us understand molecular mechanisms that contribute to hepatic fibrosis.<h4>Methods</h4>Eight-wk-old male GNMTKO (C57BL6J background) and control mice were fed AIN-76 based diet (24% casein, 60% sucrose/starch, and 5% fat) for 8 wk (n = 5-6).