The Zn-related SLC30A8 SNP rs13266634 modified the association of estimated D5D activity with T2D risk (p-interaction = 0.014): a stronger inverse association was observed in individuals with the CT- or TT-genotypes (HR = 0.66, 95% CI 0.55–0.78) compared to those with the CC-genotype (HR = 0.91, 95% CI 0.77–1.08) (Table 3). The gene discussed is SLC30A8; the disease is type 2 diabetes mellitus.