Among helper T (Th) cells, Th17 cells have long been considered the main contributors to psoriasis pathogenesis, primarily through their release of pro‐inflammatory cytokines such as IL‐17 [1, 2, 3] However, accumulating evidence has highlighted the pivotal roles of CD8+ T cells in disease pathogenesis [4, 5, 6]. The gene discussed is CD8A; the disease is psoriasis.