For example, in a mouse model of ischemic stroke, microglia‐specific PGC‐1α overexpression suppresses NLRP3 inflammasome activation; reduces TNF‐α, IL‐1β, and IL‐6 production; enhances mitophagy; and significantly improves neurological outcomes [80]. The gene discussed is PPARGC1A; the disease is ischemic stroke.