Excess myoglobin can subsequently lead to renal tubular obstruction, direct nephrotoxicity, and acute tubular necrosis.[19] Izzedine et al reported that dysferlin loss in podocytes led to mitochondrial cytopathy with neurodegeneration and brain iron accumulation, characterized by proteinuria and microscopic hematuria. The gene discussed is DYSF; the disease is acute kidney tubular necrosis.