However, subsequent studies showed that VPS13C encodes a lipid transfer protein localized at contact sites between the endoplasmic reticulum and late endosomes/lysosomes.[7,8] Recent findings suggest that VPS13C contributes to PD pathogenesis through dysregulation of several lysosomal pathways.[9] Lipid transport mediated by VPS13C via a bridge-like mechanism may play a role in preventing or repairing the rupture of the lysosomal membrane. The gene discussed is VPS13C; the disease is Parkinson disease.