The most common toxic side effects are bone marrow suppression, nausea and vomiting, and fatigue.[70] Colonizing human granulocyte stimulating factor is effective in ameliorating neutropenia induced during chemotherapy.[71] And nausea and vomiting are well controlled after application of a standard antiemetic protocol.[72] According to relevant trails, treatments combined with PD1 inhibitors did not increase in chemotherapy related toxic side effects. Here, PDCD1 is linked to neutropenia.