This study, along with previous ones, confirms that mitochondrial metabolic abnormalities and immune cell imbalance are associated with RA.[14,59] Through cross-validation of multiple algorithms, a multigene combination of COX7B, NDUFB3, and UQCRQ was screened out, the lncRNA NEAT1/miRNA regulatory axis was revealed, and pathways shared with neurodegenerative diseases were discovered, forming differences by virtue of the systematicness of the analysis strategy and the integration of tools. The gene discussed is NDUFB3; the disease is rheumatoid arthritis.