CD4 and rheumatoid arthritis: The box plot demonstrated that compared to the control group, the levels of CD8 T cells, naive CD4 T cells, regulatory T cells (Tregs), and activated natural killer cells were significantly reduced in the RA group, while resting CD4 memory T cells, activated CD4 memory T cells, gamma delta T cells, and M2 macrophages showed a high level of abundance (P < .05) (Fig. 5b, Table S6, Supplemental Digital Content, https://links.lww.com/MD/P915).