NDUFB3 and rheumatoid arthritis: Also, it could induce NLRP3 activation and pyroptosis.[32] In RA, NDUFB3 showed high expression in plasma cells and was closely connected with the onset and progression of the disease.[30,33] Functioning as a subunit of ubiquinol-cytochrome c reductase (complex III), this protein was found to be upregulated in RA.