COX7B and neurodegenerative disease: This study, along with previous ones, confirms that mitochondrial metabolic abnormalities and immune cell imbalance are associated with RA.[14,59] Through cross-validation of multiple algorithms, a multigene combination of COX7B, NDUFB3, and UQCRQ was screened out, the lncRNA NEAT1/miRNA regulatory axis was revealed, and pathways shared with neurodegenerative diseases were discovered, forming differences by virtue of the systematicness of the analysis strategy and the integration of tools.