CDK5 and Parkinson disease: Overexpression of miR-124 can silence CDK5 activity through inhibition of calpain1/p25/CDK5 signaling cascade.[46] Liu finds that acupuncture applied to acupoints Yanglingquan(GB34) and Taichong(LR3) can up-regulate miR-124 expression within the striatal region of PD transgenic murine models.[115]