BDNF and Alzheimer disease: Consequently, BDNF is recognized as a pivotal mediator of neuroplasticity, crucial for motor learning and poststroke recovery.[1] Conversely, impairments in BDNF signaling or its reduced expression are strongly implicated in the pathogenesis of conditions like Alzheimer (AD) and PD.[2,3] Furthermore, BDNF modulates dopamine receptor expression, underscoring its broader involvement in the pathophysiology of psychiatric conditions such as schizophrenia and mood disorders.[4,5] Therefore, BDNF may be an effective therapeutic target to treat NDs.