H3K4me3 activation-driven Mettl3 transcription promotes intrahepatic cholangiocarcinoma progression through YTHDF2-mediated interferon induced protein with tetratricopeptide repeats 2 (IFIT2) mRNA degradation, and IFIT2 acts as a tumor suppressor.[63] During the process of bone metastasis in HCC, it has been discovered that Mettl3 and YTHDF1 play a role in enhancing the stability of anillin actin-binding protein (ANLN) mRNA through the regulation of m6A modification. The gene discussed is IFIT2; the disease is intrahepatic cholangiocarcinoma.