For example, Mettl3 promotes the m6A modification of Hsa_circ_0058493, which promotes its intracellular localization from the nucleus to the cytoplasm in an m6A-dependent manner by binding to YTHDC1, thereby affecting the growth and metastasis of HCC.[111] Has_circ_000858 was also found to bind directly to miR-1301-3p, and Mettl3 is a target of miR-1301-3p. The gene discussed is METTL3; the disease is hepatocellular carcinoma.