PD-L1, as a kind of immunosuppressive factor, helps to form a special tumor microenvironment in pancreatic cancer, which can evade immune surveillance and improve the ability of pancreatic cancer cells to survive.[74] It was also found that linc-UROD was stabilized by Mettl3-induced m6A methylation, then recognized by IGF2BP3. Here, CD274 is linked to familial pancreatic carcinoma.