The Notch signaling pathway is a highly conserved pathway known to regulate various aspects of cancer biology, and its activation has been shown to promote tumorigenesis.[87] By modulating the m6A modification of NOTCH1 mRNA, Mettl3 can influence the stability and expression of NOTCH1, thereby potentially impacting the activation of the Notch signaling pathway. The gene discussed is NOTCH1; the disease is cancer.