Has_circ_0008583 accelerates the proliferation, migration and invasion of HCC cells by regulating the miR-1301-3p/METTL3 pathway.[112] In addition, circ-CCT3 can be bound by Alk B homolog 5 and Mettl3 and undergo m6A modification, then circ-CCT3 up-regulates the expression of VEGFR1 through sponging miR-378a-3p. The gene discussed is METTL3; the disease is hepatocellular carcinoma.