METTL3 and cancer: Interestingly, it has been observed that Mettl3 negatively regulates LINC01273 expression, forming a regulatory feedback loop.[65] LncRNA NIFK-AS1 was also found to reduce the injection transporter of sorafenib, making it insensitive to sorafenib treatment in HCC cells.[66] A separate study focused on autophagy, known to be associated with chemo-resistance in human cancers.