METTL3 and hepatocellular carcinoma: In HCC, mitogen stimulation can trigger SUMOylation of Mettl3, and the SUMOylated Mettl3 promotes the progression of HCC by regulating the homeostasis of Snail mRNA and affecting the accumulation of Snail.[55] One study discovered that sulfatide-induced acetylation led to a reduction in the Mettl3-Mettl14-WTAP complex, which in turn resulted in decreased m6A methylation.