Methylation of PLK1 is essential for the maintenance of the pancreatic cancer cell cycle, and increased Mettl3 may also create a favorable environment for fibroblasts around the tumor and promote tumor growth.[79] Perineural invasion is a typical neuropathological change of pancreatic carcinoma, which is considered a unique metastatic pathway. The gene discussed is METTL3; the disease is familial pancreatic carcinoma.