METTL3 and colorectal cancer: As a downstream target of Mettl3, Crumbs3 expression is negatively regulated by Mettl3 in an m6A-YTHDF2-dependent manner, thus promoting the proliferation and invasion of colorectal cancer.[35] Mettl3 was also found to promote basic helix-loop-helix family member E41 expression in an m6A-dependent manner, which in turn induces transcription of C-X-C motif chemokine ligand 1.