The overexpression of Mettl3 suppresses the expression of LINC01559, which enhances the proliferation and metastasis of colorectal cancer cells.[105] In addition, the overexpression of LINC01605, facilitated by H3K4me3 and epigenetic modification to histone 3 modifications, can bind to Mettl3 and enhance the m6A modification of non-erythrocytic 2 mRNA. The gene discussed is METTL3; the disease is colorectal cancer.