LDHA catalyzes the conversion of pyruvate to lactate, triggering glycolysis and 5-FU resistance.[48] Cancer-associated fibroblast-derived exosomal miR181d5p was also found to inhibit sensitivity to 5-FU by targeting neurocalcin δ, while Mettl3-dependent upregulation of m6A methylation promotes recognition of pri-mir-181d by microprocessor DiGeorge syndrome critical region 8 and processing of mature miR181d5p, promoting miR181d5p formation.[49] Oxaliplatin, a third-generation platinum drug, is widely used to treat colorectal cancer. The gene discussed is METTL3; the disease is cancer.