The intricate interplay between Mettl3, IGF2BP3, SMS, AKT phosphorylation, and EMT activation sheds light on the underlying mechanisms driving pancreatic cancer progression.[73] It was found that Mettl3 positively regulates the expression of lncRNA metastasis associated lung adenocarcinoma transcript 1 in pancreatic cancer cells, and metastasis associated lung adenocarcinoma transcript 1 increases the expression of programmed death-ligand 1 (PD-L1) in pancreatic cancer cells. This evidence concerns the gene SMS and familial pancreatic carcinoma.