Silencing hepatitis B x-interacting protein (HBXIP) inhibits Mettl3, which impairs the m6A modification of MYC mRNA, thereby inhibiting gastric cancer cell proliferation, migration, and invasion.[24,25] Moreover, Mettl3 regulates the stability of pre-B-cell leukemia homeobox 1 mRNA through m6A modification, and pre-B-cell leukemia homeobox 1 acts as a transcription factor to induce the expression of GTP cyclohydrolase 1, the rate-limiting enzyme in tetrahydrobiopterin biosynthesis. This evidence concerns the gene PBX1 and gastric cancer.