C-X-C motif chemokine ligand 1 is a chemotaxis-stimulating factor that strongly inhibits the antitumor activities of T cells and natural killer cells by recruiting myeloid-derived suppressor cells, thus impairing antitumor immunity and ultimately promoting colorectal cancer.[36] Reprogramming of energy metabolism has emerged as a prominent hallmark of cancer. This evidence concerns the gene CXCL1 and colorectal cancer.