DBH antisense RNA 1 inhibits the ability of pancreatic tumors to grow in vivo and increases the sensitivity of pancreatic cancer cells to gemcitabine by isolating miR-3163 and promoting the upregulation of ubiquitin specific peptidase 44, which is involved in the uptake of gemcitabine.[108] One study found that the Mettl3/IGF2BP1 complex mediated m6A methylation of the lncRNA NIFK-AS1 and enhanced its stability in HCC, whereas high levels of NIFK-AS1 promoted AKT1 expression by sponging miR-637. This evidence concerns the gene METTL3 and familial pancreatic carcinoma.