Additionally, downregulating the expression of both Mettl3 and WTAP is involved in slowing the progression of esophageal carcinoma.[93] In addition, in the study of therapeutic mechanism of esophageal cancer, it was found that the zinc-finger transcription factor EGR1 was the target of Mettl3. This evidence concerns the gene METTL3 and carcinoma of esophagus.