As a tyrosine-protein kinase, VEGFR1 plays a key role in cell survival, angiogenesis, cell invasion and migration, and its overexpression promotes the growth and metastasis of HCC.[113] HBV × protein (HBx) is a major driver of HBV-related HCC, which can upregulate the expression of Mettl3 and increase the m6A modification and expression of circARL3. The gene discussed is METTL3; the disease is hepatocellular carcinoma.