Conversely, downregulation of ASPM could inhibit the proliferation, migration and invasion of hepatoma cells.[57] Similarly, Mettl3 also regulates the expression of ubiquitin-specific peptidase 7 through m6A methylation, which promotes the invasion, migration and proliferation of HCC cells.[58] In HCC, TAMs play a role in the tumor microenvironment by influencing M1 and M2 polarization. The gene discussed is USP7; the disease is hepatocellular carcinoma.