CD274 and familial pancreatic carcinoma: LIFR-AS1 can positively regulate VEGFA expression in pancreatic cancer cells via serving as a ceRNA for miR-150-5p, activating VEGFA-mediated AKT/mTOR signaling pathway, and promoting pancreatic cancer progression.[76] CircRNA MYO1C is modified by Mettl3, which induces its circularization, and then interacts with PD-L1 through IGF2BP2 recognition, which promotes the stability of PD-L1 mRNA and promotes the proliferation and migration of tumor cells.[77] In addition, Mettl3 and Mettl14 have been identified as critical regulators of m6A modification on miR-380-3p.