METTL3 and gastric adenocarcinoma: Studies have shown that knockout of Mettl3 using CRISPR/Cas9 technology reduces m6A methylation levels in AGS cells (gastric adenocarcinoma cell line), leading to a noticeable inhibition of cell proliferation.[20] Several mRNAs have been identified as promoters of gastric cancer progression due to their interaction with Mettl3.