Albumin showed the strongest effect among laboratory markers, both as a continuous measure (HR 1.18 per 0.1 g/dL decrease, p < 0.001) and as a categorical variable (<3.5 g/dL; HR 2.11, p < 0.001), indicating a substantial increase in risk among patients with hypoalbuminemia. The gene discussed is ALB; the disease is Hypoalbuminemia.