TGM2 and Cowden disease: Classic CD (gastrointestinal symptoms such as diarrhea, malabsorption, failure to thrive, and presence of tTG and/or EMA antibodies and/or MARSH ≥ 2), non-classic/atypical CD (silent or nonspecific symptoms like abdominal pain, constipation, presence of tTG, and/or EMA antibodies and/or MARSH ≥ 2), subclinical CD (no clinical symptoms, presence of tTG and/or EMA antibodies and/or MARSH ≥ 2), and potential CD (presence of tTG and/or EMA antibodies, no clinical symptoms, no histopathological changes) [8,9].