Glucagon-like peptide-1 receptor agonists (GLP-1RA) (e.g., semaglutide, liraglutide) may also be of some benefit for patients with HF but their predominate role is in lowering the risk of stroke and peripheral artery disease and only modestly improving LVEF in HF patients [55,56,57,58,59,60,61]. The gene discussed is GLP1R; the disease is Stroke.