PLAT and cardiovascular disorder: According to an analysis of the Framingham Offspring Cohort, which consisted of 3223 adults free of cardiovascular disease, light-to-moderate alcohol consumption (3–7 drinks/week) is correlated with lower levels of fibrinogen, plasma viscosity, vWF, and factor VII, while higher levels of consumption are associated with reduced fibrinolytic activity, as shown by higher levels of plasminogen activator inhibitor antigen-1 (PAI-1) and tissue plasminogen activator (TPA) antigen [45].