In the Citicoline Group, the individual changes in DTI metrics (increase in FA and AD and a reduction in MDi and RD) detected in both left and right optic radiation and LGN were associated with the observed shortening of RCT, without reaching the level of significance (ranging from r = 0.391, p = 0.081 for AD optic radiations right vs. RCT to r = 0.551, p = 0.054 for RD LGN right vs. RCT). Here, GPSM2 is linked to Alzheimer disease.