Studies on specific diseases revealed the role of endothelin 1 in the development of hypertensive kidney disease [36], IgA nephropathy [37,38], focal and segmental glomerulosclerosis [39], diabetic nephropathy [40], acute kidney injury [41], ischemia–reperfusion injury [41], polycystic kidney disease [42], sickle cell nephropathy [43], and systemic sclerosis [44]. Here, EDN1 is linked to IgA glomerulonephritis.