Correlations between initial plasma endothelin 1 concentrations and initial serum creatinine concentrations (n = 30; p = 0.03; r = −0.38) (Figure 21) and serum creatinine concentrations following 1 month of monitoring (n = 30; p = 0.05; r = −0.36) (Figure 22) in the focal and segmental glomerulosclerosis cohort were statistically significantly negative. The gene discussed is EDN1; the disease is focal segmental glomerulosclerosis.