The median plasma levels of endothelin 1 levels were recorded at 0.63 (0–53) pg/mL for the membranous nephropathy cohort; 0.57 (0–53) pg/mL for the focal and segmental glomerulosclerosis cohort; 0.50 (0–10.94) pg/mL for the systemic lupus erythematosus cohort; 0.44 (0–20.03) pg/mL for the IgA nephropathy cohort; 0.24 (0–4.49) pg/mL for the mesangial proliferative (non-IgA) glomerulonephritis cohort; 2.01 (0.32–30.21) pg/mL for the hemodialysis cohort; 1.18 (0.5–44.78) pg/mL for the chronic kidney disease cohort; and 1.46 (0.32–53) pg/mL for the control group. This evidence concerns the gene EDN1 and chronic kidney disease.