A higher frequency of hospitalization for MCE was associated with a greater presence of hypertension, diabetes, HF, atrial fibrillation, cardiomegaly, and a higher prescription of angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists, diuretics, digoxin, or anticoagulants, as well as a higher platelet count; and with lower haemoglobin levels, glomerular filtration rate, lower frequency of previous revascularization and treatment with antiplatelet drugs and statins (Table 1). The gene discussed is ACE; the disease is atrial fibrillation.