These findings can also explain the beneficial effects that treatment with GLP-1 RA had on insulin resistance, with a statistically significant reduction in TG/HDLc ratio (with an average of 1.04) and in TyG index (with an average of 0.16), both surrogate markers of insulin resistance, suggesting improved insulin sensitivity as also shown in multiple other trials and meta-analyses [23,24,25]. The gene discussed is GLP1R; the disease is Insulin resistance.