MFN2 and Charcot-Marie-Tooth disease type 2A1: One of the most common inherited axonal neuropathies, Charcot-Marie-Tooth disease type 2A (CMT2A), is caused by dominant mutations in MFN2 (Mitofusin 2 deficiency), classified by the ICIMD under group 19 (Disorders of organelle biogenesis, dynamics, and interactions).