BMP2 and neurofibromatosis type 1: Moreover, the administration of asfotase alfa and bisphosphonates in combination with surgical intervention and rhBMP-2 (recombinant human Bone Morphogenetic Protein-2) resulted in solid arthrodesis and enhanced bone healing in a patient with NF1-related dystrophic scoliosis, suggesting that enhanced bone formation, resorption, and mineralisation may be associated with better outcomes [67].