In the murine DCM model, Western blotting confirmed increased CX3CR1 protein levels at both the ~50 kDa and ~55 kDa isoforms in WT DCM mice at 10 weeks compared with WT shams (Figure 3A,B; n = 4; one-way ANOVA with Sidak post hoc tests, p < 0.01). This evidence concerns the gene CX3CR1 and familial dilated cardiomyopathy.