Among the most well-known gene alterations of brain tumors, there are mutations of isocitrate dehydrogenase (IDH) 1 and 2 gene, whole arm deletion of chromosome arms 1p and 19q, mutations of the Telomerase Reverse Transcriptase (TERT) promoter, amplifications and mutations of Human Epithelial Growth Factor Receptor (EGFR), and mutations of B-Raf proto-oncogene, serine/threonine kinase (BRAF) [6]. The gene discussed is BRAF; the disease is brain neoplasm.