It has been observed that decreases in the Tiffeneau–Pinelli index and forced expiratory volume in 1 s (FEV1) are associated with an increased level of high sensitivity to CRP (hs CRP), and the risk of ischemic heart disease is higher in patients with moderate-to-severe obstruction and higher CRP levels [4,49]. The gene discussed is CRP; the disease is coronary artery disorder.