In parallel, a serrated neoplasia pathway—characterized by v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) mutations, CpG island methylator phenotype (CIMP) and frequent MLH1 promoter hypermethylation—gives rise to a substantial subset of right-sided and microsatellite-unstable cancers [8]. Here, BRAF is linked to cancer.