INS and diabetes mellitus: Trials demonstrating the largest improvements (such as Olsen et al. [25] and Wang et al. [24]) were those incorporating protocol-driven insulin titration, predefined alarm-response algorithms, and active involvement of diabetes specialists, whereas studies with limited clinical responsiveness to CGM information (e.g., Spanakis et al. [23], Thabit et al. [26]) showed attenuated or null effects.