EDN2 and Renal insufficiency: Specifically, the Mdn ET-2 levels were 19.32 pg/mL (IQR = 14.58) in the control group (Group 1), rising to 25.15 pg/mL (IQR = 10.54) in patients with moderate dysfunction (Group 2), and 24.49 pg/mL (IQR = 8.62) in the severe renal failure group (Group 3).