Long-lived stromal and adipose progenitor populations can retain obesity-imposed regulatory states that shape the phenotype of newly generated adipocytes, while the post-obesity microenvironment—characterized by TGFβ-driven extracellular matrix remodeling, senescence-associated secretory signaling, and persistent organelle stress—may further stabilize inflammatory set-points despite fat mass reduction [94]. Here, TGFB1 is linked to Obesity.