These melanoma-private mutations occurred in genes linked to chromatin regulation (ARID1A and ARID2), cell growth (e.g., PIK3CA), cell adhesion (e.g., EPHA2), splicing (SF3B1), angiogenesis (PTPRB), and classic tumor suppressors (NOTCH3, CDKN2A, and PTEN). Here, PIK3CA is linked to melanoma.