These melanoma-private mutations occurred in genes linked to chromatin regulation (ARID1A and ARID2), cell growth (e.g., PIK3CA), cell adhesion (e.g., EPHA2), splicing (SF3B1), angiogenesis (PTPRB), and classic tumor suppressors (NOTCH3, CDKN2A, and PTEN). The gene discussed is NOTCH3; the disease is neoplasm.