Nevi most often harbored canonical MAPK-pathway mutations in BRAF and NRAS, as well as in GRIN2A, while melanomas, along with BRAF and NRAS, frequently carried additional driver alterations in ARID1A, ARID2, CDKN2A, and PTEN (Table 1, Figure 2). This evidence concerns the gene GRIN2A and melanoma.