For example, (hsa_circRNA_101522, Chr.15, exonic (DMXL2)), whose host gene DMXL2 is reported to drive EMT and promote endocrine therapy resistance in breast cancer through Notch pathway hyperactivation [52], was found to be specifically upregulated among the top 20 circRNAs in three comparisons: TNBC vs. Luminal, TNBC vs. Luminal A, and TNBC vs. Luminal B. This evidence concerns the gene DMXL2 and breast cancer.