DOT1L and cancer: We identified several TNBC-specific alterations in methyltransferase enzymes related to cancer pathogenesis, such as SMYD4 (involved in breast cancer progression) [48,49], EHMT1, DOT1L, Zinc Finger CCHC-Type Containing 4 (ZCCHC4), a modifier of 28S ribosomal RNA (rRNA) with a crucial role in mRNA translation and cancer chemoresistance [50,51], METTL8, CARM1, AS3MT, and METTL5 (Figure 8, Supplemental Table S5).