TFRC and COVID-19: Local perturbations of iron handling are also evident in affected tissues: autopsy lung analyses from fatal COVID-19 cases demonstrate increased ferritin light chain (FTL), upregulation of transferrin receptor 1 (TFRC/TfR1), and elevated lipid-peroxidation products (MDA, 4-HNE), findings consistent with local iron accumulation and ferroptotic injury [202].