Further, ACSL4 regulation can be influenced by cellular stress pathways: in glioma cells, heat shock protein Hsp90 and dynamin-related protein 1 (Drp1) dephosphorylation stabilize ACSL4 expression during erastin-induced ferroptosis, promoting mitochondrial fragmentation and lipid peroxidation [347]. Here, ACSL4 is linked to glioma.