In a myocardial infarction (MI) model induced by left anterior descending (LAD) coronary artery ligation in mice, administration of Fer-1 lowered levels of redox-active (ferrous) iron, reduced lipid peroxidation (MDA), restored GSH, and enhanced expression of GPX4 and cystine/glutamate antiporter (a transporter that imports cystine into the cell in exchange for glutamate) xCT encoded by the SLC7A11 gene, thereby attenuating infarct size and myocardial injury [148]. The gene discussed is GPX4; the disease is myocardial infarction.