GPX4 and Alzheimer disease: Complementary evidence from AD mouse models demonstrates iron buildup and heightened lipid peroxidation in cortex and hippocampus, and interventions that reduce iron content or inhibit ferroptosis—such as iron chelators, GPX4 overexpression, or activation of the Xc−/GPX4 pathway—consistently mitigate neurodegeneration and improve cognitive outcomes [113,115,116].