AKT1 and cancer: In cancer models, cannabinoids have been shown to enhance the cytotoxic efficacy of conventional chemotherapeutics (e.g., cisplatin, 5-fluorouracil, and doxorubicin) by promoting oxidative stress, inhibiting the PI3K/AKT/mTOR signaling pathway, and amplifying autophagy-mediated apoptosis [19,20].