In models of periodontitis and gingival inflammation, cannabinoids modulate the release of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), influence macrophage polarization toward a reparative phenotype, and promote the autophagic clearance of damaged organelle processes that collectively contribute to the resolution of inflammation and restoration of tissue homeostasis [11]. The gene discussed is TNF; the disease is periodontitis.