IPA from SIV- to SIV+ comparison showed enrichment of pathways such as hypercytokinemia/hyperchemokinea in viral infection (CASP1, CXCL10, IFIT3, IL1RN, IRF7, IRF9, ISG15, MX1, OAS2), pathogen-induced cytokine storm signaling (CCL7, CD163, CGAS, CXCL10, CXCL11, SPI1, DHX58, TLR1, TLR3, TLR7, TLR8), and interferon signaling (CCL7, CD86, ICAM1, JAK2, LAT2, MYD88, NLRC5) (Figure 1B). This evidence concerns the gene DHX58 and viral infectious disease.