SPI1 and viral infectious disease: IPA from SIV- to SIV+ comparison showed enrichment of pathways such as hypercytokinemia/hyperchemokinea in viral infection (CASP1, CXCL10, IFIT3, IL1RN, IRF7, IRF9, ISG15, MX1, OAS2), pathogen-induced cytokine storm signaling (CCL7, CD163, CGAS, CXCL10, CXCL11, SPI1, DHX58, TLR1, TLR3, TLR7, TLR8), and interferon signaling (CCL7, CD86, ICAM1, JAK2, LAT2, MYD88, NLRC5) (Figure 1B).