IPA from SIV- to SIV+ comparison showed enrichment of pathways such as hypercytokinemia/hyperchemokinea in viral infection (CASP1, CXCL10, IFIT3, IL1RN, IRF7, IRF9, ISG15, MX1, OAS2), pathogen-induced cytokine storm signaling (CCL7, CD163, CGAS, CXCL10, CXCL11, SPI1, DHX58, TLR1, TLR3, TLR7, TLR8), and interferon signaling (CCL7, CD86, ICAM1, JAK2, LAT2, MYD88, NLRC5) (Figure 1B). The gene discussed is IRF9; the disease is viral infectious disease.