Pathways involving hypercytokinemia/hyperchemokinea in viral infection (CXCL10, IFIT3, IRF7, ISG15, MX1, OAS2), pathogen-induced cytokine storm signaling (CCL7, CCL8, CD163, DHX58, TLR1, TLR3, CXCL10, CXCL11, IL21R), and interferon signaling (IFI6, IFIT1, IFIT3, ISG15, MX1, OAS1, STAT1, STAT2, TAP1) (Figure 1E) were all downregulated in SIV+/ART animals compared to SIV+ animals. The gene discussed is TLR1; the disease is viral infectious disease.