In comparison with both controls (isotype IgG (IgG) control and no antibody (CTL) treated cells), the levels of leptin, LDLR, ACAT1 and Apo- B were reduced in anti-MUC1 antibody (Mab) treated in all three of the cancer cell lines (MCF-7, CSC and PANC). The gene discussed is LDLR; the disease is cancer.