TNF and breast cancer: To try to further find out the difference between the effect of TA-MUC1 and LPS on cancer cells, our other study using an LPS-created inflammatory cell model showed that under LPS treatment, the level of inflammatory factors (TNF-α—M1 macrophage marker) along with several coagulation elements (TF, prothrombin, thrombin and factor X (FX)) were significantly increased in breast cancer cells (sh-Ctrl MCF-7), in contrast to the only slight increase in TA-MUC1 knock down cancer cells (sh-MUC1 MCF7 cell) (Supplementary Figure S1).