RYR2 and heart failure: Since an increase in RyR2 phosphorylation at Ser2808 occurs via protein kinase A-dependent activation of β-adrenergic receptors, we posit that β-blockers may also be useful not only in older HIV-infected individuals with heart failure but also in younger PWH to blunt hyperadrenergic activity, attenuate the PKA-dependent gain-of-function of RyR2, prolongation in the QT interval and risk for ventricular tachyarrhythmia.