RYR2 and Ventricular arrhythmia: The model also shows for the first time phosphorylation of RyR2 at Ser2808 is increased in hearts from HIV-1-infected and HIV-1-infected animals treated with DTG/TDF/FTC, suggesting aberrant release of Ca2+ from the SR during diastole could be increasing the risk of ventricular arrhythmias and cardiac arrest.