NRG1 and Candidemia: Building on our prior discovery that EVs promote fungal proliferation via L-arginine/NO-mediated reduction of ROS and apoptosis [52], this study elucidates a counter-regulatory mechanism: EVs suppress hyphal morphogenesis and systemic virulence by upregulating SKO1 to enhance the repressor activity of Nrg1, ultimately attenuating candidemia (Figure 8).