However, it is important to critically evaluate whether elevated IL-1β, IL-18, or caspase-1 levels in cerebrospinal fluid truly reflect NLRP3-dependent neuroinflammation in PD, as these cytokines can also be produced through inflammasome-independent mechanisms and may represent broader systemic or neuroinflammatory states rather than specific NLRP3 activation [48,49]. This evidence concerns the gene NLRP3 and Parkinson disease.