SIRT1 and Parkinson disease: In the central nervous system, these same pathways translate into reduced oxidative and endoplasmic reticulum stress, attenuation of neuroinflammation, and modulation of disease-specific lesions: in multiple models of Alzheimer’s and Parkinson’s disease berberine lowers ROS, upregulates NRF2/HO-1 and SIRT1–FOXO1 signaling, promotes autophagic clearance of Aβ and hyperphosphorylated tau, and reduces caspase activation and glial activation, leading to improved cognition and motor behavior, albeit almost exclusively in preclinical studies [71].