Experimental data summarized by Fang et al. show that BBR upregulates mitochondrial content and UCP1 (Uncoupling Protein 1)-mediated thermogenesis in brown and beige adipocytes, modulates fission/fusion dynamics via DRP1 (Dynamin-related protein 1), and promotes mitophagy through PINK1–Parkin and BNIP3/HIF-1α (BCL2 Interacting Protein 3/Hypoxia-Inducible Factor-1 alpha) pathways in cardiomyocytes, thereby limiting ischemia–reperfusion injury and pressure-overload–induced heart failure [20]. The gene discussed is HIF1A; the disease is ischemia.