Regarding the expression of luminal and basal biomarkers, Layer3.1 tumor presented higher expression of KRT20, a luminal-papillary biomarker, whereas Layer3.2 had higher expression of KRT5, KRT6a, KRT14, and CD44 basal biomarkers, but also PGM5, DES, and SGCD luminal-infiltrated biomarkers (Supplementary Figure S7). Here, CD44 is linked to neoplasm.