In parallel, one of the most direct and recent pieces of evidence that mDCs are indeed OCps in vivo derived from a set of serial gene target experiments by Puchner et al., where CD11c-diphtheria toxin/DT-receptor mice (CD11c-DTR) were treated with DT via serum transfer for arthritis (STA) and hTNF-transgenic arthritis mice (hTNF-tg) via clinical histo-morphometry, and those OCs/OCps were analyzed in CD11c-vs. Here, ITGAX is linked to arthritic joint disease.