The objective of the study of Farrell et al. [78] was to determine whether an anthocyanin-rich S. nigra fruit extract (13% anthocyanins) would protect against inflammation-related impairments in high-density lipoprotein (HDL) function and atherosclerosis in apoE(−/−) mice (a mouse model of hyperlipidemia and HDL dysfunction). Here, APOE is linked to atherosclerosis.