A comparative analysis of mitochondrial proteomics between ovarian cancer SKOV3 cells and A2780 cells demonstrated that FDX1, the copper transporter SLC31A1 (CTR1), ATP7A, and the copper chaperone proteins SCO1, SCO2, and antioxidant 1 copper chaperone (ATOX1), which are associated with complex IV, were all significantly upregulated in A2780 cells (Figure 4C). The gene discussed is SCO1; the disease is ovarian cancer.