These observations, together with the prominent expression of IFNγ within the TLSs, are consistent with the results arising from previous studies performed on B cell lymphomas and nasopharyngeal carcinoma, demonstrating that EBNA2 induces PD-L1 on EBV infected B cells, acting in synergistic manner with IFNγ [17,74]. Here, IFNG is linked to B-cell non-Hodgkin lymphoma.