NDDs may be caused by a mutation in one gene, e.g., TBR1 (MIM *604616) correlated with intellectual developmental disorder with autism and speech delay (MIM #606053), or may concern multiple genes, leading to chromosomal aberrations, e.g., 7q11.23 duplication, typically associated with speech and language delay, motor delay, intellectual disability, anxiety, autism, or 16p11.2 deletion—common features include developmental delay, speech impairment, intellectual disability, or autism, behavioral problems, hypotonia, seizures, and increased weight gain [3]). Here, TBR1 is linked to Intellectual disability.