According to the Online Mendelian Inheritance in Man (OMIM; https://omim.org/about, accessed on 24 April 2024), pathogenic variants of the PAK1 gene (so far only missense variants) were described in association with inTellectual Developmental Disorder with Macrocephaly, Seizures, and Speech Delay in an autosomal dominant mode of inheritance (MIM #618158). This evidence concerns the gene PAK1 and Seizure.