Multiple cutting-edge studies have indicated that gadolinium-based nanoparticles combined with radiotherapy can enhance immunogenic cell death and reshape the tumor immune microenvironment [205,206,207]; when combined with PD-1/PD-L1 inhibitors, not only does local lesion control improve, but also a remote effect amplification can be observed in bilateral or metastasis models, even in low-dose irradiation scenarios [208,209,210]. The gene discussed is CD274; the disease is neoplasm.