TRIM21 and Sjogren syndrome: Furthermore, because miR-16-5p has been implicated in autoantibody-associated immune activation and has been linked to Ro52/TRIM21 in other autoimmune conditions, it will be important in future work to determine whether tear or ocular surface miR-16-5p correlates with Ro/La autoantibody titers and Ro52/TRIM21 expression in patients with Sjögren’s syndrome.